IL-1RN and IL-1β Polymorphism and ARV-Associated Hepatotoxicity. (8th April 2018)

• Record Type: Journal Article
• Authors: Singh, HariOm; Samani, Dharmesh; Nema, Vijay; Ghate, Manisha V.; Gangakhedkar, R. R.
• Other Names: Petricevich Vera L. Academic Editor.
• Is Part Of: Mediators of inflammation. Volume 2018(2018)
• Publication Date: 2018-04-08
• Subjects: Inflammation -- Mediators -- Periodicals; Biological response modifiers -- Periodicals; Inflammation (Pathologie) -- Médiateurs; Immunomodulateurs; Biological response modifiers; Inflammation -- Mediators; Immunology; Autacoids; Immunologic Factors; Cell Adhesion Molecules; Cell Communication; Cytokines; Inflammation; Periodicals; Electronic journals; 616.0473
• DOI: 10.1155/2018/4398150
• Languages: English
• ISSNs: 0962-9351

Abstract

Abstract : The severity of hepatic injury depends upon cytokines. Previous studies associated IL-1RN allele 2 with IL-1β production. Hence, we examined the association of IL-1 RN and IL-1β polymorphisms with ARV-associated hepatotoxicity. Genotyping of IL-1RN (VNTR), IL-1β (-511C/T) polymorphisms was done in 162 HIV-infected patients, 34 with ARV hepatotoxicity, 128 without hepatotoxicity, and 152 healthy controls using PCR and PCR-RFLP method. The haplotypes 1T and 2C enhanced the risk for severe hepatotoxicity (OR = 1.41, P = 0.25 ;OR = 1.67, P = 0.31 ). IL-1β- 511TT genotype significantly represented among tobacco using HIV-infected individuals compared to nonusers (OR = 3.74, P = 0.05 ). IL-1β- 511TT genotype among alcohol users increased the risk for hepatotoxicity (OR = 1.80, P = 0.90 ). IL-1β- 511CT and - 511TT genotypes overrepresented in alcohol using HIV-infected individuals (OR = 2.29, P = 0.27 ;OR = 2.64, P = 0.19 ). IL-RN 2/2 and 1/3 genotypes represented higher in nevirapine using hepatotoxicity patients (OR = 1.42, P = 0.64, OR = 8.79, P = 0.09 ). IL-1β- 511CT and - 511 TT genotypes among nevirapine users enhanced the risk for severe hepatotoxicity (OR = 4.29, P = 0.20 ;OR = 1.95, P = 0.56 ). IL-1β- 511CT and - 511TT genotypes were overrepresented in combined nevirapine and alcohol using HIV-infected individuals as compared to nevirapine users and alcohol nonusers (OR = 2.56, P = 0.26 ;OR = 2.84, P = 0.24 ). IL-1β- 511TT genotype with tobacco, alcohol, and nevirapine usage revealed a trend of risk for the development of ARV-associated hepatotoxicity and its severity.