DHA Supplementation during Pregnancy and Lactation Affects Infants' Cellular but Not Humoral Immune Response. (14th July 2011)

• Record Type: Journal Article
• Authors: Granot, Esther; Jakobovich, Einat; Rabinowitz, Ruth; Levy, Paloma; Schlesinger, Michael
• Other Names: Fantuzzi Giamila Academic Editor.
• Is Part Of: Mediators of inflammation. Volume 2011(2011)
• Publication Date: 2011-07-14
• Subjects: Inflammation -- Mediators -- Periodicals; Biological response modifiers -- Periodicals; Inflammation (Pathologie) -- Médiateurs; Immunomodulateurs; Biological response modifiers; Inflammation -- Mediators; Immunology; Autacoids; Immunologic Factors; Cell Adhesion Molecules; Cell Communication; Cytokines; Inflammation; Periodicals; Electronic journals; 616.0473
• DOI: 10.1155/2011/493925
• Languages: English
• ISSNs: 0962-9351

Abstract

Abstract : Background . It is currently recommended that diet of pregnant mothers contain 200–300 mg DHA/day. Aim . To determine whether DHA supplementation during pregnancy and lactation affects infants' immune response. Methods . 60 women in ≥3rd pregnancy studied; 30 randomly assigned to receive DHA 400 mg/day from 12th week gestation until 4 months postpartum. From breast-fed infants, blood obtained for anti-HBs antibodies, immunoglobulins, lymphocyte subset phenotyping, and intracellular cytokine production. Results . CD4+ lymphocytes did not differ between groups, but CD4CD45RA/CD4 (naïve cells) significantly higher in infants in DHA+ group. Proportion of CD4 and CD8 cells producing IFN γ significantly lower in DHA+ group, with no differences in proportion of IL4-producing cells. Immunoglobulins and anti-HBs levels did not differ between groups. Conclusions . In infants of mothers receiving DHA supplementation, a higher percentage of CD4 naïve cells and decreased CD4 and CD8 IFN γ production is compatible with attenuation of a proinflammatory response.