CD4+ TSCMs in the Bone Marrow Assist in Maturation of Antibodies against Influenza in Mice. (10th January 2019)

• Record Type: Journal Article
• Authors: Wu, Kang; Wang, Fei; Guo, Guangwu; Li, Yuqing; Qiu, Li-Jun; Li, Xuefeng
• Other Names: Fu Bishi Guest Editor.
• Is Part Of: Mediators of inflammation. Volume 2019(2019)
• Publication Date: 2019-01-10
• Subjects: Inflammation -- Mediators -- Periodicals; Biological response modifiers -- Periodicals; Inflammation (Pathologie) -- Médiateurs; Immunomodulateurs; Biological response modifiers; Inflammation -- Mediators; Immunology; Autacoids; Immunologic Factors; Cell Adhesion Molecules; Cell Communication; Cytokines; Inflammation; Periodicals; Electronic journals; 616.0473
• DOI: 10.1155/2019/3231696
• Languages: English
• ISSNs: 0962-9351

Abstract

Abstract : The bone marrow (BM) is not only a reservoir of hematopoietic stem cells but a repository of immunological memory cells. Further characterizing BM-resident memory T cells would be helpful to reveal the complicated relationship between the BM and immunological memory. In this study, we identified CD122 high stem cell antigen-1 (Sca-1) high B cell lymphoma 2 (Bcl-2) high CD4 + stem cell-like memory T cells (TSCMs) as a distinct memory T cell subset, which preferentially reside in the BM, where they respond vigorously to blood-borne antigens. Interestingly, the natural CD4 + TSCMs homing to the BM colocalized with VCAM-1 + IL-15 + IL-7 + CXCL-12 + stromal cells. Furthermore, compared to spleen-resident CD4 + TSCMs, BM-resident TSCMs induced the production of high-affinity antibodies against influenza by B lymphocytes more efficiently. Taken together, these observations indicate that the BM provides an appropriate microenvironment for the survival of CD4 + TSCMs, which broadens our knowledge regarding the memory maintenance of antigen-specific CD4 + T lymphocytes.