Direct electrosynthesis for N-alkyl-C3-halo-indoles using alkyl halide as both alkylating and halogenating building blocks. Issue 10 (29th April 2019)

• Record Type: Journal Article
• Authors: Sun, Linhao; Zhang, Xing; Wang, Chenguang; Teng, Huailong; Ma, Jimei; Li, Zilong; Chen, Hao; Jiang, Hong
• Is Part Of: Green chemistry. Volume 21:Issue 10(2019)
• Page Start: 2732
• Page End: 2738
• Publication Date: 2019-04-29
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/c9gc00913b
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : An electrochemically induced tandem reaction has been developed for selective N1-alkylation and C3-halogenation of indoles. Abstract : An electrochemically induced tandem reaction has been developed for selective N1-alkylation and C3-halogenation of indoles. This electrochemical difunctionalization strategy circumvents conventional multi-step procedures and efficiently generates synthetically important N -alkyl-3-halo-indoles under more environmentally benign conditions. This reaction can proceed in a simple undivided cell, without the use of any oxidant, base or transition-metal. The excellent atom-economy of this method is highlighted by fully using alkyl halide as both alkylating and halogenating building blocks without atom waste.