Placental mitochondrial DNA copy number is associated with reduced birth weight in women with placental malaria. (May 2019)

• Record Type: Journal Article
• Authors: Oktavianthi, Sukma; Fauzi, Muhammad; Trianty, Leily; Trimarsanto, Hidayat; Bowolaksono, Anom; Noviyanti, Rintis; Malik, Safarina G.
• Is Part Of: Placenta. Volume 80(2019)
• Page Start: 1
• Page End: 3
• Publication Date: 2019-05
• Subjects: Placental malaria -- mtDNA copy number -- Relative telomere length -- Birth weight; Placenta -- Periodicals; Reproduction -- Periodicals; Placenta -- Periodicals; Placenta -- Périodiques; Reproduction -- Périodiques; 612.63
• DOI: 10.1016/j.placenta.2019.03.005
• Languages: English
• ISSNs: 0143-4004

Abstract

Abstract: Placental malaria (PM) causes placental insufficiency, leading to reduced birth weight (BW). Placental mtDNA copy number (mtDNA-CN) and relative telomere length (RTL) have been described as potential biomarkers for placental insufficiency and intrauterine growth restriction (IUGR). We investigated their associations with BW in women with PM from malaria-endemic region of Papua, Indonesia. MtDNA-CN and RTL were determined in 50 placentas by quantitative real-time PCR. Increased placental mtDNA-CN was associated with reduced BW (coef = −193.71, p = 0.016), particularly in preterm group (coef = −374.21, p < 0.001). RTL did not associate with BW. Increased placental mtDNA-CN indicates a compensatory mechanism to reduced BW in women with PM. Highlights: Study was conducted in Timika, Papua, a highly malaria endemic region. Axillary temperature was positively related to placental mtDNA copy number. Axillary temperature was positively associated with placental relative telomere length. Increased placental mtDNA copy number was associated with reduced birth weight in women with PM.