Tenosynovial giant cell tumours of the hand: A multicentre case-control study. Issue 6 (June 2019)

• Record Type: Journal Article
• Authors: Linney, L.S.; Al-Hassani, F.; Pikturnaite, J.; Mathew, B.; Thornton, D.; Wade, R.G.; Pinder, R.M.
• Is Part Of: Journal of plastic, reconstructive & aesthetic surgery. Volume 72:Issue 6(2019)
• Page Start: 918
• Page End: 923
• Publication Date: 2019-06
• Subjects: TSGCT -- GCTTS -- Giant cell tumours -- Tumours of the hand; Surgery, Plastic -- Great Britain -- Periodicals; Reconstructive Surgical Procedures -- Periodicals; Surgery, Plastic -- Great Britain -- Periodicals; 617.9505
• DOI: 10.1016/j.bjps.2019.01.021
• Languages: English
• ISSNs: 1748-6815

Abstract

Summary: Many factors have been proposed to contribute to the risk of recurrent tenosynovial giant cell tumours (TSGCT); however, we remain unable to predict those at risk, which formed the rationale for this multicentre retrospective case-control study of 28 patients with recurrence. We included cases of recurrence in a 1:1 ratio matched for age and sex with controls over 10 years. Using Cox regression, we present hazard ratios (HRs) for recurrence with 95% confidence intervals (CIs). Out of 285 cases, 28 individuals developed recurrence after a median of 2.4 years. Recurrent TSGCT had a higher mitotic count/mm 2 in the primary tumour (median increase of 3 [IQR 1, 7]). Mitotic count in the primary tumour was associated with the risk of recurrence (adjusted HR 1.1 [95% CI 1.1, 1.2]) meaning that for every additional mitosis, the risk of recurrence increased by 10% per annum. We recommend a prospective cohort study to validate our findings.