Disperse magnetic sources constructed with functionalized Fe3O4 nanoparticles in poly-l-lactic acid scaffolds. (July 2019)

• Record Type: Journal Article
• Authors: Yang, Wenjing; Zhong, Yancheng; Feng, Pei; Gao, Chengde; Peng, Shuping; Zhao, Zhenyu; Shuai, Cijun
• Is Part Of: Polymer testing. Volume 76(2019)
• Page Start: 33
• Page End: 42
• Publication Date: 2019-07
• Subjects: Functionalization -- Disperse magnetic sources -- Magnetic scaffolds -- Bone regeneration; Polymers -- Testing -- Periodicals; Polymères -- Tests -- Périodiques; 620.1920287
• DOI: 10.1016/j.polymertesting.2019.03.008
• Languages: English
• ISSNs: 0142-9418

Abstract

Abstract: Fe3 O4 nanoparticles were widely applied as magnetic sources in scaffolds to stimulate bone regeneration. In this study, Fe3 O4 nanoparticles were successfully functionalized by oleic acid to circumvent the aggregate issue of the nanoparticles in poly- l -lactic acid (PLLA) bone scaffolds fabricated via selective laser sintering. On the one hand, carboxylic acid groups of oleic acid may interact with the hydroxyl groups of Fe3 O4 nanoparticles in case of aqueous medium, contributing to the surface functionalization of the nanoparticles. On the other hand, hydrocarbon chains of oleic acid were oriented toward the PLLA matrix and mutually exclusive, facilitating the dispersion of the nanoparticles in PLLA scaffolds. As a result, the dispersion of functionalized Fe3 O4 nanoparticles in scaffold was significantly better than that of non-functionalized nanoparticles. The magnetic scaffolds with uniformly dispersed nanoparticles (12 wt%) presented increased compressive strength and modulus by 95% and 68%, respectively, owning to the rigid enhancement effect of nanoparticles. Meanwhile, they exhibited good capabilities of cell adhesion, proliferation and differentiation, due to the magnetic stimulation for cells produced by uniformly dispersed magnetic sources. All these positive results indicated that the magnetic scaffolds showed great potential in the application of bone regeneration. Highlights: Fe3 O4 nanoparticles were successfully functionalized by oleic acid. 3D porous composite scaffolds were fabricated via SLS. Functionalized Fe3 O4 nanoparticles exhibited well dispersion in PLLA matrix. Functionalized Fe3 O4 nanoparticles enhanced mechanical properties of the PLLA scaffolds. Functionalized Fe3 O4 nanoparticles improved the cytocompatibility of PLLA scaffolds.