Genetic Cross-Talk During Head Development in Drosophila. Issue 1 (27th April 2004)

• Record Type: Journal Article
• Authors: Amin, Amr
• Is Part Of: Journal of biomedicine and biotechnology. Volume 2004:Issue 1(2004)
• Page Start: 16
• Page End: 23
• Publication Date: 2004-04-27
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Medicine; Biology; Biotechnology; Médecine; Biologie; Biotechnologie; Biology; Biotechnology; Medicine; Biotechnology; Biomedicine; Electronic journals; Periodical; Periodicals; Electronic journals; 610
• DOI: 10.1155/S1110724304302032
• Languages: English
• ISSNs: 1110-7243

Abstract

Abstract : The dorsal head vertex of Drosophila is specified mainly by the orthodenticle ( otd ) gene. The expression and the function of otd are regulated by the concerted action of many genes including hedgehog ( hh ) and notch ( N ). These genes are components of a meshwork of signaling transduction pathways that interact to form the dorsal head capsule of the fruit fly. Loss-of-function Hh mutants lack ocelli; however, loss-of-function N mutants lack a different domain of the dorsal head vertex. This report provides new evidence that the Hh and N pathways are two epistatic signaling cascades that act genetically upstream of the dorsal head capsule specification gene.