The Effect of Acid-Reducing Pharmacotherapy on the Severity of Nausea and Vomiting of Pregnancy. (1st July 2009)

• Record Type: Journal Article
• Authors: Gill, Simerpal Kaur; Maltepe, Caroline; Mastali, Katayoon; Koren, Gideon
• Other Names: Grobman William A. Academic Editor.
• Is Part Of: Obstetrics and gynecology international. Volume 2009(2009)
• Publication Date: 2009-07-01
• Subjects: Obstetrics -- Periodicals; Gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.1005
• DOI: 10.1155/2009/585269
• Languages: English
• ISSNs: 1687-9589

Abstract

Abstract : Background . Heartburn and acid reflux (HB/RF) are associated with increased severity of nausea and vomiting. The ability of acid-reducing drugs to reduce symptoms of nausea and vomiting of pregnancy has not been previously tested. Objective . To determine whether acid-reducing pharmacotherapy decreases the severity of NVP symptoms. Methods . We studied a cohort of women experiencing NVP, who were also experiencing HB/RF. Women were counseled to commence acid-reducing pharmacotherapy. The effectiveness of the acid-reducing medication in decreasing symptoms of both HB/RF and NVP was measured. Results . Acid-reducing drugs resulted in significant decreases in PUQE (9.6 ± 3.0 to6.5 ± 2.5, P < .0001 ) and well-being scores from the initial (4.0 ± 2.0 ) to the follow-up interview (6.8 ± 1.6, P < .0001 ). After intervention with acid-reducing pharmacotherapy, a reduction in acid symptoms correlated significantly with reduction in NVP (R 2 = 0.72, P < .001 ). Conclusion . This is the first study to demonstrate that management of HB/RF can reduce the severity of NVP.