Hypermethylation of SOX2 Promoter in Endometrial Carcinogenesis. (25th July 2010)

• Record Type: Journal Article
• Authors: Wong, Oscar Gee-Wan; Huo, Zhen; Siu, Michelle Kwan-Yee; Zhang, HuiJuan; Jiang, LiLi; Wong, Ester Shuk-Ying; Cheung, Annie Nga-Yin
• Other Names: Jin Fan Academic Editor.
• Is Part Of: Obstetrics and gynecology international. Volume 2010(2010)
• Publication Date: 2010-07-25
• Subjects: Obstetrics -- Periodicals; Gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.1005
• DOI: 10.1155/2010/682504
• Languages: English
• ISSNs: 1687-9589

Abstract

Abstract : This paper aimed at investigating the expression and methylation profiles of SOX2, a gene coding for the stem cell-related transcription factor SOX2, in endometrial carcinomas. By methylation-specific polymerase chain reaction (MS-PCR), the methylation status of SOX2 promoter region in 72 endometrial carcinomas and 12 normal endometrial samples was examined. Methylated allele was found in 37.5% (27/72) of endometrial carcinomas but only in 8.3% (1/12) of normal endometrial, significantly more frequent in cancers (P = .0472 ). SOX2 mRNA level was significantly reduced in endometrial carcinoma compared with nonneoplastic endometrium (P = .045 ). A significant correlation between SOX2 mRNA expression and hypermethylation of SOX2 was found (P = .024 ). Hypermethylation of SOX2 tended to be more frequently found in type II serous or clear cell adenocarcinoma. SOX2 methylation was also significantly correlated with shorter survival of patients (P = .046 ). In conclusion, epigenetic mechanisms may play a crucial role on the transcriptional regulation of SOX2 and loss of SOX2 expression may be related to endometrial carcinogenesis.