Preemptive Treatment of Nausea and Vomiting of Pregnancy: Results of a Randomized Controlled Trial. (17th February 2013)

• Record Type: Journal Article
• Authors: Maltepe, Caroline; Koren, Gideon
• Other Names: Hernandez Enrique Academic Editor.
• Is Part Of: Obstetrics and gynecology international. Volume 2013(2013)
• Publication Date: 2013-02-17
• Subjects: Obstetrics -- Periodicals; Gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.1005
• DOI: 10.1155/2013/809787
• Languages: English
• ISSNs: 1687-9589

Abstract

Abstract : Objectives . To determine whether the initiation of treatment (preemptive treatment) before the symptoms of nausea and vomiting of pregnancy (NVP) versus when the symptoms begin can improve the outcome in patients at a high risk for recurrence of severe NVP. Study Design . Prospective, randomized controlled trial. Results . Preemptive therapy conferred a significant reduction in HG as compared to the previous pregnancy (P = 0.047) . In the preemptive arm, there were 2.5-fold fewer cases of moderate-severe cases of NVP than those in the control group (15.4% versus 39.13%) in the first 3 weeks of NVP (P = 0.05) . In the preemptive group, significantly more women had their NVP resolved before giving birth (78.2% versus 50%) (P < 0.002) . Conclusions . Preemptive treatment with antiemetics is superior to the treatment that starts only when the symptoms have already occurred in decreasing the risk of severe forms of NVP.