Central Corneal Thickness in Spectral-Domain OCT and Associations with Ocular and Systemic Parameters. (2nd June 2016)

• Record Type: Journal Article
• Authors: Schuster, Alexander Karl-Georg; Fischer, Joachim Ernst; Vossmerbaeumer, Urs
• Other Names: Han Sang Beom Academic Editor.
• Is Part Of: Journal of ophthalmology. Volume 2016(2016)
• Publication Date: 2016-06-02
• Subjects: Ophthalmology -- Periodicals; Eye Diseases; Ophthalmology; Ophthalmology; Electronic journals; Periodicals; Periodicals; Fulltext; Internet Resources; Periodicals; 617.7
• DOI: 10.1155/2016/2596956
• Languages: English
• ISSNs: 2090-004X

Abstract

Abstract : Background . Optical coherence tomography (OCT) allows quantitative analysis of the anterior segment of the eye with a noncontact examination. The aim of this study is to analyze associations of central corneal thickness (CCT) as measured by OCT with ocular and systemic cardiovascular parameters. Methods . A cross-sectional study of 734 persons was performed in a working age population. Only healthy eyes were included. A comprehensive ophthalmological examination including refraction, noncontact tonometry, and imaging of the anterior segment by SD-OCT was performed. In parallel, a broad range of systemic cardiovascular parameters were measured. Associations were analyzed using a generalized estimating equations' model. Results . CCT measurements showed a significant association with corneal curvature and intraocular pressure: a thinner CCT was associated with a flatter cornea and with lower intraocular pressure (p < 0.001 ). Age was positively associated with CCT (p < 0.001 ); all other cardiovascular parameters were not associated. Conclusion . A thinner cornea is associated with a flatter surface and with lower intraocular pressure readings, while there are no independent associations with refraction and systemic cardiovascular parameters. Our findings highlight the value of SD-OCT CCT measurements as a standard tool in anterior segment analysis.