Decreased Perifoveal Sensitivity Detected by Microperimetry in Patients Using Hydroxychloroquine and without Visual Field and Fundoscopic Anomalies. (12th March 2015)

• Record Type: Journal Article
• Authors: Molina-Martín, A.; Piñero, D. P.; Pérez-Cambrodí, R. J.
• Other Names: Teoh Stephen Charn Beng Academic Editor.
• Is Part Of: Journal of ophthalmology. Volume 2015(2015)
• Publication Date: 2015-03-12
• Subjects: Ophthalmology -- Periodicals; Eye Diseases; Ophthalmology; Ophthalmology; Electronic journals; Periodicals; Periodicals; Fulltext; Internet Resources; Periodicals; 617.7
• DOI: 10.1155/2015/437271
• Languages: English
• ISSNs: 2090-004X

Abstract

Abstract : Purpose . To evaluate the usefulness of microperimetry in the early detection of the ocular anomalies associated with the use of hydroxychloroquine. Methods . Prospective comparative case series study comprising 14 healthy eyes of 7 patients (group A) and 14 eyes of 7 patients under treatment with hydroxychloroquine for the treatment of rheumatologic diseases and without fundoscopic or perimetric anomalies (group B). A comprehensive ophthalmological examination including microperimetry (MP) and spectral-domain optical coherence tomography was performed in both groups. Results . No significant differences were found in mean MP foveal sensitivity between groupsP = 0.18 . However, mean MP overall sensitivity was significantly higher in group A (29.05 ± 0.57 dB versus group B, 26.05 ± 2.75 dB;P < 0.001 ). Significantly higher sensitivity values were obtained in group A in comparison to group B for the three eccentric loci evaluatedP < 0.001 . Conclusion . Microperimetry seems to be a useful tool for the early detection of retinal damage in patients treated with hydroxychloroquine.