Falsely low activated clotting time measured in a patient with sickle cell trait. (May 2019)

• Record Type: Journal Article
• Authors: Crook, Richard; Wheeler, Kyrie
• Is Part Of: Perfusion. Volume 34:Number 4(2019)
• Page Start: 334
• Page End: 336
• Publication Date: 2019-05
• Subjects: cardiopulmonary bypass -- sickle cell; Perfusion (Physiology) -- Periodicals; Blood -- Circulation, Artificial -- Periodicals; Heart -- Surgery -- Periodicals; Extracorporeal Circulation -- Periodicals; Perfusion -- Periodicals; Circulation extracorporelle -- Périodiques; Perfusion -- Périodiques; 617.41
• DOI: 10.1177/0267659118822945
• Languages: English
• ISSNs: 0267-6591

Abstract

Sickle cell anaemia results from homozygosity of an A-T point mutation leading to a substitution of glutamic acid for valine at point 6 of the β-globin gene. A person with sickle cell trait inherits one normal and one mutated allele. Patients with sickle cell anaemia, and to a lesser extent sickle cell trait, have a wide spectrum of haemostatic abnormalities. Here we describe the problems faced in obtaining an accurate activated clotting time measurement, in a patient with sickle cell trait, prior to commencement of cardiopulmonary bypass for decannulation of Berlin Heart.