Interleukin-10: A Key Cytokine in Depression?. (4th August 2009)

• Record Type: Journal Article
• Authors: Roque, Susana; Correia-Neves, Margarida; Mesquita, Ana Raquel; Palha, Joana Almeida; Sousa, Nuno
• Other Names: Manev Hari Academic Editor.
• Is Part Of: Cardiovascular psychiatry and neurology. Volume 2009(2009)
• Publication Date: 2009-08-04
• Subjects: Cardiovascular system -- Diseases -- Periodicals; Cardiovascular system -- Diseases -- Psychological aspects -- Periodicals; Psychiatry -- Periodicals; Cardiology -- Periodicals; Neurology -- Periodicals; Nervous system -- Diseases -- Periodicals; Cardiology; Cardiovascular system -- Diseases; Cardiovascular system -- Diseases -- Psychological aspects; Nervous system -- Diseases; Neurology; Psychiatry; Cardiovascular Diseases -- complications; Nervous System Diseases -- complications; Mental Disorders -- complications; Cardiology; Neurology; Psychiatry; Cardiovascular Diseases -- complications -- Periodicals; Nervous System Diseases -- complications -- Periodicals; Mental Disorders -- complications -- Periodicals; Cardiology -- Periodicals; Neurology -- Periodicals; Psychiatry -- Periodicals; Periodicals; Electronic journals; 616.81
• DOI: 10.1155/2009/187894
• Languages: English
• ISSNs: 2090-0163

Abstract

Abstract : An increasing body of evidence implicates proinflammatory cytokines in psychiatric disorders, namely, in depression. Of notice, recent studies showed that anti-inflammatory cytokines, such as IL-10, also modulate depressive-like behavior. In this article, we propose that the anti-inflammatory cytokine IL-10 is a putative link between two of the most widely reported phenomenon observed in depressed patients: the disruption of the hypothalamic-pituitary-adrenal axis and the imbalanced production of cytokines. If so, IL-10 might represent a novel target for antidepressant therapy.