Duration of Type 2 Diabetes and Very Low Density Lipoprotein Levels Are Associated with Cognitive Dysfunction in Metabolic Syndrome. (24th June 2014)

• Record Type: Journal Article
• Authors: Yogi-Morren, Divya; Galioto, Rachel; Strandjord, Sarah Elizabeth; Kennedy, L.; Manroa, Pooja; Kirwan, John P.; Kashyap, Sangeeta; Gunstad, John
• Other Names: Hirata Koichi Academic Editor.
• Is Part Of: Cardiovascular psychiatry and neurology. Volume 2014(2014)
• Publication Date: 2014-06-24
• Subjects: Cardiovascular system -- Diseases -- Periodicals; Cardiovascular system -- Diseases -- Psychological aspects -- Periodicals; Psychiatry -- Periodicals; Cardiology -- Periodicals; Neurology -- Periodicals; Nervous system -- Diseases -- Periodicals; Cardiology; Cardiovascular system -- Diseases; Cardiovascular system -- Diseases -- Psychological aspects; Nervous system -- Diseases; Neurology; Psychiatry; Cardiovascular Diseases -- complications; Nervous System Diseases -- complications; Mental Disorders -- complications; Cardiology; Neurology; Psychiatry; Cardiovascular Diseases -- complications -- Periodicals; Nervous System Diseases -- complications -- Periodicals; Mental Disorders -- complications -- Periodicals; Cardiology -- Periodicals; Neurology -- Periodicals; Psychiatry -- Periodicals; Periodicals; Electronic journals; 616.81
• DOI: 10.1155/2014/656341
• Languages: English
• ISSNs: 2090-0163

Abstract

Abstract : Type 2 diabetes (T2D) is now recognized as an independent risk factor for accelerated cognitive decline and neurological conditions like Alzheimer's disease. Less is known about the neurocognitive function of T2D patients with comorbid metabolic syndrome, despite their elevated risk for impairment. Computerized testing in 47 adults with T2D that met criteria for NCEP metabolic syndrome revealed that cognitive impairment was prevalent, including 13% in tests of memory, 50% in attention, and 35% in executive function. Partial correlations showed that longer duration of diabetes was associated with poorer performance on tests of basic attention (r = - 0.43 ), working memory (r = 0.43 ), and executive function (r = 0.42 ). Strong associations between very low density lipoprotein and poor cognitive function also emerged, including tests of set shifting (r = 0.47 ) and cognitive inhibition (r = - 0.51 ). Findings suggest that patients with T2D that meet criteria for metabolic syndrome are at high risk for cognitive impairment. Prospective studies should look to replicate these findings and examine the possible neuroprotective effects of lipid-lowering medication in this population.