Plasmablastic Lymphoma in an Immunocompetent Patient with MDS/MPN with Ring Sideroblasts and Thrombocytosis—A Case Report. (4th November 2018)

• Record Type: Journal Article
• Authors: Bouchla, Anthi; Papageorgiou, Sotirios G.; Tsakiraki, Zoi; Glezou, Eirini; Pavlidis, George; Stavroulaki, Georgia; Bazani, Efthimia; Foukas, Periklis; Pappa, Vasiliki
• Other Names: Piccaluga Pier P. Academic Editor.
• Is Part Of: Case reports in hematology. Volume 2018(2018)
• Publication Date: 2018-11-04
• Subjects: Hematology -- Periodicals; Hematology -- Case studies -- Periodicals; Blood -- Diseases -- Periodicals; Hematology; Hematologic Diseases; Blood -- Diseases; Hematology; Electronic journals; Periodicals; Case studies; Periodicals; Case Reports; Fulltext; Internet Resources; Periodicals; 616.15
• DOI: 10.1155/2018/2525070
• Languages: English
• ISSNs: 2090-6560

Abstract

Abstract : Plasmablastic lymphoma (PBL) is a rare, aggressive type of B-cell non-Hodgkin lymphoma with the vast majority of patients responding poorly to treatment or progressing shortly thereafter. Cyclophosphamide-doxorubicin-vincristine-prednisolone (CHOP) or CHOP-like regimens have disappointing results in this setting. We report a case of PBL arising in a previously diagnosed myelodysplastic/myeloproliferative (MDS/MPN) with ring sideroblasts and thrombocytopenia (RS-T), HIV-negative patient treated with the combination of CHOP and bortezomib. The patient achieved complete metabolic response, which has lasted one year, longer by far than would have been expected with the sole use of CHOP.