Baseline Antibody Titre against Salmonella enterica in Healthy Population of Mumbai, Maharashtra, India. (31st August 2017)

• Record Type: Journal Article
• Authors: Patki, Rucha; Lilani, Sunil; Lanjewar, Dhaneshwar
• Other Names: Iglewski Barbara H. Academic Editor.
• Is Part Of: International journal of microbiology. Volume 2017(2017)
• Publication Date: 2017-08-31
• Subjects: Microbiology -- Periodicals; Microbiology; Microbiology -- Periodicals; Electronic journals; Periodicals; 579
• DOI: 10.1155/2017/9042125
• Languages: English
• ISSNs: 1687-918X

Abstract

Abstract : Objective . The aim of this study was to establish a baseline titre for the population of Mumbai, Maharashtra, India. Method . Four hundred healthy blood donors, attending blood donation camps, were screened using a survey questionnaire. Widal tube agglutination test was performed on the diluted sera (with 0.9% normal saline) of blood donors, with final dilution ranging from 1 : 40 to 1 : 320. Results . Out of 400 individuals providing samples, 78 (19.5%) individuals showed antibody titres ≥ 1 : 40 for at least one antigen and 322 (80.5%) showed no agglutination. The baseline antibody titres against O antigen and H antigen of Salmonella enterica serotype Typhi were found to be 1 : 40 and 1 : 80, respectively. Similarly, the baseline antibody titres for the H antigen of Salmonella enterica serotypes Paratyphi A and Paratyphi B were found to be 1 : 40 and 1 : 80, respectively. Conclusion . Thus, it was noted that the diagnostically significant cutoff of antibody titre from acute phase sample was ≥ 1 : 80 for S. Typhi O antigen and titre of ≥ 1 : 160 for both S. Typhi H antigen and S. Paratyphi BH antigen. Antibody titre of ≥ 1 : 80 can be considered significant for S. Paratyphi AH antigen.