Limited Weight Loss or Simply No Weight Gain following Lifestyle-Only Intervention Tends to Redistribute Body Fat, to Decrease Lipid Concentrations, and to Improve Parameters of Insulin Sensitivity in Obese Children. (14th March 2011)

• Record Type: Journal Article
• Authors: Marcano, Henry; Fernández, Maricelia; Paoli, Mariela; Santomauro, Mercedes; Camacho, Nolis; Cichetti, Rosanna; Molina, Zarela; Valeri, Lenin; Lanes, Roberto
• Other Names: Hofman Paul L. Academic Editor.
• Is Part Of: International journal of pediatric endocrinology. Volume 2011(2011)
• Publication Date: 2011-03-14
• Subjects: Pediatric endocrinology -- Periodicals; Endocrine glands -- Diseases -- Periodicals; 618.924
• DOI: 10.1155/2011/241703
• Languages: English
• ISSNs: 1687-9856

Abstract

Abstract : Objectives . To investigate whether lifestyle-only intervention in obese children who maintain or lose a modest amount of weight redistributes parameters of body composition and reverses metabolic abnormalities. Study Design . Clinical, anthropometric, and metabolic parameters were assessed in 111 overweight or obese children (CA of 11.3 ± 2.8 years; 63 females and 48 males), during 8 months of lifestyle intervention. Patients maintained or lost weight (1–5%) (group A; n: 72) or gained weight (group B). Results . Group A patients presented with a decrease in systolic blood pressure (SBP) and diastolic blood pressure (DBP) (P < . 005 andP < . 05, resp.), BMI (P < . 0001 ), z-score BMI (P < . 0001 ), waist circumference (P < . 0001 ), fat mass (P < . 005 ), LDL-C (P < . 05 ), Tg/HDL-C ratio (P < . 05 ), fasting and postprandial insulin (P < . 005 ), and HOMA (P < . 005 ), while HDL-C (P < . 05 ) and QUICKI increased (P < . 005 ). Conversely, group B patients had an increase in BMI (P < . 0001 ), waist circumference (P < . 005 ), SBP (P < . 005 ), and in QUICKI (P < . 005 ), while fat mass (P < . 05 ), fasting insulin (P < . 05 ), and HOMA (P < . 05 ) decreased. Lean mass, DBP, lipid concentrations, fasting and postprandial glucose, postprandial insulin, and ultrasensitive C-reactive protein (CRP) remained stable. Conclusions . Obese children who maintain or lose a modest amount of weight following lifestyle-only intervention tend to redistribute their body fat, decrease blood pressure and lipid levels, and to improve parameters of insulin sensitivity.