High Prevalence of Associated Birth Defects in Congenital Hypothyroidism. (4th May 2010)

• Record Type: Journal Article
• Authors: Reddy, P. Amaresh; Rajagopal, G.; Harinarayan, C. V.; Vanaja, V.; Rajasekhar, D.; Suresh, V.; Sachan, Alok
• Other Names: Root Allen W. Academic Editor.
• Is Part Of: International journal of pediatric endocrinology. Volume 2010(2010)
• Publication Date: 2010-05-04
• Subjects: Pediatric endocrinology -- Periodicals; Endocrine glands -- Diseases -- Periodicals; 618.924
• DOI: 10.1155/2010/940980
• Languages: English
• ISSNs: 1687-9856

Abstract

Abstract : Aim . To identify dysmorphic features and cardiac, skeletal, and urogenital anomalies in patients with congenital hypothyroidism. Patients and Methods . Seventeen children with congenital primary hypothyroidism were recruited. Cause for congenital hypothyroidism was established using ultrasound of thyroid andT 99 m c radionuclide thyroid scintigraphy. Malformations were identified by clinical examination, echocardiography, X-ray of lumbar spine, and ultrasonography of abdomen. Results . Ten (59%) patients (6 males and 4 females) had congenital malformations. Two had more than one congenital malformation (both spina bifida and ostium secundum atrial septal defect). Five (29%) had cardiac malformations, of whom three had only osteum secundum atrial septal defect (ASD), one had only patent ductus arteriosus (PDA), and one patient had both ASD and PDA. Seven patients (41%) had neural tube defects in the form of spina bifida occulta. Conclusion . Our study indicates the need for routine echocardiography in all patients with congenital hypothyroidism.