Changes in B-Cell Counts and Percentages during Primary HIV Infection Associated with Disease Progression in HIV-Infected Men Who Have Sex with Men: A Preliminary Study. (7th September 2015)

• Record Type: Journal Article
• Authors: Cui, Chen; Jiang, Yongjun; Zhang, Zining; Hu, Qinghai; Chu, Zhenxing; Xu, Junjie; Zhao, Bin; Ding, Haibo; Liu, Jing; Han, Xiaoxu; Cao, Yaming; Shang, Hong
• Other Names: Soares Marcelo A. Academic Editor.
• Is Part Of: BioMed research international. Volume 2015(2015)
• Publication Date: 2015-09-07
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2015/468194
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : Numerous anomalies in B-cell phenotypes and functions have been described in HIV-infected individuals. However, the actual relationship between B cells and disease progression remains unclear. In this study, we investigated B-cell counts/percentages during a 12-month infection period in HIV-infected individuals that eventually developed into typical progressors (TPs) or rapid progressors (RPs). We found, after 12 months of infection, the baseline B-cell counts/percentages correlated positively with CD4 + T-cell counts (P = 0.0006 andP = 0.026 ) and negatively with HIV viral set points (P = 0.014 andP = 0.002 ). Kaplan-Meier survival analysis showed that high baseline B-cell counts/percentages were associated with a slow CD4-cell decline. B-cell kinetics indicated the baseline B-cell counts/percentages could be factors distinguishing between TPs and RPs. The combination of the baseline B-cell counts and percentages was associated with rapid disease progression (a 80.7% predictive value as measured by the area under the curve). These results indicate that the baseline B-cell counts/percentages might be associated with HIV disease progression.