Cytotoxic and Bactericidal Effect of Silver Nanoparticles Obtained by Green Synthesis Method Using Annona muricata Aqueous Extract and Functionalized with 5-Fluorouracil. (15th October 2018)

• Record Type: Journal Article
• Authors: Sánchez-Navarro, María del Carmen; Ruiz-Torres, Claudio Adrian; Niño-Martínez, Nereyda; Sánchez-Sánchez, Roberto; Martínez-Castañón, Gabriel Alejandro; DeAlba-Montero, I.; Ruiz, Facundo
• Other Names: Tabacaru Aurel Guest Editor.
• Is Part Of: Bioinorganic chemistry and applications. Volume 2018(2018)
• Publication Date: 2018-10-15
• Subjects: Bioinorganic chemistry -- Periodicals; Bioinorganic chemistry; Biochemistry; Inorganic Chemistry; Chemistry, Bioinorganic; Periodicals; 572.51
• DOI: 10.1155/2018/6506381
• Languages: English
• ISSNs: 1565-3633

Abstract

Abstract : Nanomaterials obtained by green synthesis technologies have been widely studied in recent years owing to constitute cost-effective and environmental-friendly methods. In addition, there are several works that report the simultaneous performance of the reducer agent as a functionalizing agent, modifying the properties of the nanomaterial. As a simple and economical synthesis methodology, this work presents a method to synthesize silver nanoparticles (AgNPs) using Annona muricata aqueous extract and functionalized with 5-fluorouracil (5-FU). The processes of reduction, nucleation, and functionalization of the nanoparticles were analyzed by UV-Vis absorption spectroscopy, and it was found that they are the function of the contact time of the metal ions with the extract. The structural characterization was carried out by transmission electron microscopy (TEM) and X-ray diffraction patterns (XRD). The antibacterial properties of the synthetized nanomaterials were tested using minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against Enterococcus faecalis, Staphylococcus aureus, and Escherichia coli growth.