A Review on Platelet Activating Factor Inhibitors: Could a New Class of Potent Metal-Based Anti-Inflammatory Drugs Induce Anticancer Properties?. (28th March 2017)

• Record Type: Journal Article
• Authors: Papakonstantinou, Vasiliki D.; Lagopati, Nefeli; Tsilibary, Effie C.; Demopoulos, Constantinos A.; Philippopoulos, Athanassios I.
• Other Names: López Concepción Academic Editor.
• Is Part Of: Bioinorganic chemistry and applications. Volume 2017(2017)
• Publication Date: 2017-03-28
• Subjects: Bioinorganic chemistry -- Periodicals; Bioinorganic chemistry; Biochemistry; Inorganic Chemistry; Chemistry, Bioinorganic; Periodicals; 572.51
• DOI: 10.1155/2017/6947034
• Languages: English
• ISSNs: 1565-3633

Abstract

Abstract : In this minireview, we refer to recent results as far as the Platelet Activating Factor (PAF) inhibitors are concerned. At first, results of organic compounds (natural and synthetic ones and specific and nonspecific) as inhibitors of PAF are reported. Emphasis is given on recent results about a new class of the so-called metal-based inhibitors of PAF. A small library of 30 metal complexes has been thus created; their anti-inflammatory activity has been further evaluated owing to their inhibitory effect against PAF in washed rabbit platelets (WRPs). In addition, emphasis has also been placed on the identification of preliminary structure-activity relationships for the different classes of metal-based inhibitors.