Metal-Based Biologically Active Compounds: Synthesis, Spectral, and Antimicrobial Studies of Cobalt, Nickel, Copper, and Zinc Complexes of Triazole-Derived Schiff Bases. (19th December 2011)

• Record Type: Journal Article
• Authors: Singh, Kiran; Kumar, Yogender; Puri, Parvesh; Sharma, Chetan; Aneja, Kamal Rai
• Other Names: Katsaros Nick Academic Editor.
• Is Part Of: Bioinorganic chemistry and applications. Volume 2011(2011)
• Publication Date: 2011-12-19
• Subjects: Bioinorganic chemistry -- Periodicals; Bioinorganic chemistry; Biochemistry; Inorganic Chemistry; Chemistry, Bioinorganic; Periodicals; 572.51
• DOI: 10.1155/2011/901716
• Languages: English
• ISSNs: 1565-3633

Abstract

Abstract : A series of cobalt, nickel, copper, and zinc complexes of bidentate Schiff bases derived from the condensation reaction of 4-amino-5-mercapto-3-methyl/ethyl-1, 2, 4-triazole with 2, 4-dichlorobenzaldehyde were synthesized and tested as antimicrobial agents. The synthesized Schiff bases and their metal complexes were characterized with the aid of elemental analyses, magnetic moment measurements, spectroscopic and thermogravimetric techniques. The presence of coordinated water in metal complexes was supported by infrared and thermal gravimetric studies. A square planar geometry was suggested for Cu(II) and octahedral geometry proposed for Co(II), Ni(II), and Zn(II) complexes. The Schiff bases and their metal complexes have been screened for antibacterial ( Pseudomonas aeruginosa, Bacillus subtilis ) and antifungal activities ( Aspergillus niger, A. flavus ). The metal complexes exhibited significantly enhanced antibacterial and antifungal activity as compared to their simple Schiff bases.