Synthesis and Characterization of the Ligand Based on Benzimidazole and Its Copper Complex: DNA Binding and Antioxidant Activity. (21st November 2011)

• Record Type: Journal Article
• Authors: Wu, Huilu; Kou, Fan; Jia, Fei; Liu, Bin; Yuan, Jingkun; Bai, Ying
• Other Names: Butler Ian Academic Editor.
• Is Part Of: Bioinorganic chemistry and applications. Volume 2011(2011)
• Publication Date: 2011-11-21
• Subjects: Bioinorganic chemistry -- Periodicals; Bioinorganic chemistry; Biochemistry; Inorganic Chemistry; Chemistry, Bioinorganic; Periodicals; 572.51
• DOI: 10.1155/2011/105431
• Languages: English
• ISSNs: 1565-3633

Abstract

Abstract : A new copper(II) complex with formulae of [Cu(buobb)2 ](pic)2, where buobb stands for the ligand of 1, 3-bis(1- butylbenzimidazol-2-yl)-2-oxopropane and pic represents 2, 4, 6-trinitrophenol, has been synthesized and characterized by elemental analyses, molar conductivity, IR, UV-Vis spectra measurements, and cyclic voltammetry. The crystal structure of the copper(II) complex has been determined by X-ray single-crystal diffraction. The coordination environment around each copper(II) atom can be described as a distorted octahedral geometry. The π - π stacking interactions link the copper(II) complex into a 1D infinite network. The interactions of the ligand and the copper(II) complex with calf thymus DNA (CT-DNA) are investigated by using electronic absorption titration, ethidium bromide-DNA displacement experiments, and viscosity measurements. Additionally, the copper(II) complex's antioxidant properties have been investigated in vitro.