PPARα/γ-Independent Effects of PPARα/γ Ligands on Cysteinyl Leukotriene Production in Mast Cells. (9th November 2008)

• Record Type: Journal Article
• Authors: Yamashita, Masamichi
• Other Names: Gregoire Francine M. Academic Editor.
• Is Part Of: PPAR research. Volume 2008(2008)
• Publication Date: 2008-11-09
• Subjects: Peroxisomes -- Periodicals; Peroxisomal disorders -- Periodicals; 571.65505
• DOI: 10.1155/2008/293538
• Languages: English
• ISSNs: 1687-4757

Abstract

Abstract : Peroxisome proliferator-activated receptor (PPAR)α ligands (Wy-14, 643, and fenofibrate) and PPARγ ligands (troglitazone and ciglitazone) inhibit antigen-induced cysteinyl leukotriene production in immunoglobulin E-treated mast cells. The inhibitory effect of these ligands on cysteinyl leukotriene production is quite strong and is almost equivalent to that of the anti-asthma compound zileuton. To develop new aspects for anti-asthma drugs the pharmacological target of these compounds should be clarified. Experiments with bone-marrow-derived mast cells from PPARα knockout mice and pharmacological inhibitors of PPARγ suggest that the inhibitory effects of these ligands are independent of PPARsα andγ . The mechanisms of the PPAR-independent inhibition by these agents on cysteinyl leukotriene production are discussed in this review.