Placental Implications of Peroxisome Proliferator-Activated Receptors in Gestation and Parturition. (16th December 2007)

• Record Type: Journal Article
• Authors: Borel, Valerie; Gallot, Denis; Marceau, Geoffroy; Sapin, Vincent; Blanchon, Loïc
• Other Names: Froment Pascal Academic Editor.
• Is Part Of: PPAR research. Volume 2008(2008)
• Publication Date: 2007-12-16
• Subjects: Peroxisomes -- Periodicals; Peroxisomal disorders -- Periodicals; 571.65505
• DOI: 10.1155/2008/758562
• Languages: English
• ISSNs: 1687-4757

Abstract

Abstract : The placenta is a transitory structure indispensable for the proper development of the embryo and fetus during mammalian gestation. Like other members of the nuclear receptor family, the peroxisome proliferator-activated receptors (PPARs) are known to be involved in the physiological and pathological events occurring during the placentation. This placental involvement has been recently reviewed focusing on the early stages of placental development (implantation and invasion, etc.), mouse PPARs knockout phenotypes, and cytotrophoblast physiology. In this review, we describe the placental involvement of PPARs (e.g., fat transport and metabolism, etc.) during the late stages of gestation and in the amniotic membranes, highlighting their roles in the inflammation process (e.g., chorioamnionitis), metabolic disorders (e.g., diabetes), and parturition.