Pros and Cons of Antigen-Presenting Cell Targeted Tumor Vaccines. (25th October 2015)

• Record Type: Journal Article
• Authors: Goyvaerts, Cleo; Breckpot, Karine
• Other Names: Gilham David E. Academic Editor.
• Is Part Of: Journal of immunology research. Volume 2015(2015)
• Publication Date: 2015-10-25
• Subjects: Immunology -- Periodicals; Immunology -- Research -- Periodicals; 616.07905
• DOI: 10.1155/2015/785634
• Languages: English
• ISSNs: 2314-8861

Abstract

Abstract : In therapeutic antitumor vaccination, dendritic cells play the leading role since they decide if, how, when, and where a potent antitumor immune response will take place. Since the disentanglement of the complexity and merit of different antigen-presenting cell subtypes, antitumor immunotherapeutic research started to investigate the potential benefit of targeting these subtypes in situ . This review will discuss which antigen-presenting cell subtypes are at play and how they have been targeted and finally question the true meaning of targeting antitumor-based vaccines.