Botulinum Toxin A Injection for Treatment of Chronic Skin Ulcer: A Case Series and Literature Review. (March 2019)

• Record Type: Journal Article
• Authors: Zhong, Jiaojiao; Lan, Yu; Fu, Shuying; Zhang, Jing; Lu, Sha; He, Yunan; Zhang, Jun-min
• Is Part Of: International journal of lower extremity wounds. Volume 18:Number 1(2019:Mar.)
• Page Start: 97
• Page End: 103
• Publication Date: 2019-03
• Subjects: botulinum toxin A -- chronic skin ulcer -- treatment -- case report; Leg -- Wounds and injuries -- Periodicals; Wounds and injuries -- Prevention -- Periodicals; Leg -- Ulcers -- Periodicals; Wound healing -- Periodicals; 617.584
• DOI: 10.1177/1534734618816589
• Languages: English
• ISSNs: 1534-7346

Abstract

Chronic skin ulcer (CSU) often combines with a variety of refractory factors that respond poorly to routine treatments. Botulinum toxin A (BTX-A) can be injected subcutaneously to improve the local blood supply, to reduce pain, and to promote wound healing. At present, few reports have mentioned BTX-A injection for chronic skin ulcer treatment. We observed the effect of four cases that used BTX-A to treat CSU and provided a brief review of the literature. Four cases of CSUs with 4 different causes were treated with BTX-A injection (4 U/cm 2 ). The specific operation is as follows: local, multipoint, cyclic, equidistant, and subcutaneous injections with a depth of 6 to 8 mm. The ulcer area was significantly reduced. Subsequently, the ulcer healed within 20 to 48 days. Botulinum toxin A is recommended as an important treatment for chronic skin ulcer that can improve healing of skin ulcers with various etiologies.