WY-14643, a Potent Peroxisome Proliferator Activator Receptor-α PPAR-α Agonist Ameliorates the Inflammatory Process Associated to Experimental Periodontitis. (8th December 2010)

• Record Type: Journal Article
• Authors: Briguglio, Enrico; Di Paola, Rosanna; Paterniti, Irene; Mazzon, Emanuela; Oteri, Giacomo; Cordasco, Giancarlo; Cuzzocrea, Salvatore
• Other Names: Drew Paul Academic Editor.
• Is Part Of: PPAR research. Volume 2010(2010)
• Publication Date: 2010-12-08
• Subjects: Peroxisomes -- Periodicals; Peroxisomal disorders -- Periodicals; 571.65505
• DOI: 10.1155/2010/193019
• Languages: English
• ISSNs: 1687-4757

Abstract

Abstract : We have investigated the effects of WY14643, a potent peroxisome proliferator activator receptor-α (PPAR-α ) agonist, in a rat model of ligature-induced periodontitis. Male Sprague-Dawley rats were lightly anaesthetized with pentobarbitone (35 mg/kg). Sterile, 2-0 black braided silk thread was placed around the cervix of the lower left first molar and knotted medially. Animals received WY14643 (1 mg/kg i.p, daily for eight days). Eighths days after placement of the ligature, we evaluated several markers of inflammation such us (1) myeloperoxidase activity, (2) a cytokines and adhesion molecules expression, (3) NF- κ B expression, (4) iNOS expression, (5) the nitration of tyrosine residues, (6) activation of the nuclear enzyme poly(ADP-ribose) polymerase, (7) apoptosis, and (8) the degree of gingivomucosal tissues injury. Administration of WY14643 significantly decreased all of the parameters of inflammation as described above. These results demonstrate that WY14643 exerts an anti-inflammatory role during experimental periodontitis and is able to ameliorate the tissue damage.