Changes in the 24 h Rhythmicity of Liver PPARs and Peroxisomal Markers When Feeding Is Restricted to Two Daytime Hours. (14th March 2011)

• Record Type: Journal Article
• Authors: Rivera-Zavala, Julieta B.; Báez-Ruiz, Adrián; Díaz-Muñoz, Mauricio
• Other Names: Hardwick James P. Academic Editor.
• Is Part Of: PPAR research. Volume 2011(2011)
• Publication Date: 2011-03-14
• Subjects: Peroxisomes -- Periodicals; Peroxisomal disorders -- Periodicals; 571.65505
• DOI: 10.1155/2011/261584
• Languages: English
• ISSNs: 1687-4757

Abstract

Abstract : Restricted feeding (RF) during daytime is associated with anticipatory activity before feeding, marked hyperphagia after mealtime, adjustments in hepatic metabolism, and the expression of a food-entrained oscillator (FEO). 24 h rhythmicity of liver PPAR α, β, and γ, peroxisomal markers (PMP70, AOX, and catalase), and free fatty acids (FFAs) during RF was evaluated. The effect of fasting-refeeding was also studied. Results showed (1) higher levels of FFA before feeding, (2) a shift of PPAR α and PPAR γ before and of PPAR β peaks after feeding, (3) an increase in peroxisomal markers, (4) a shift of PMP70 and AOX peaks before feeding, and of maximal catalase activity in the dark period, (5) changes in the fasting-refeeding response, and (6) high correlations (>0.9) of serum corticosterone with PPAR α and PPAR γ and of PMP70 with PPAR β . In conclusion, 24 h rhythmicity of FFA, liver PPARs, and peroxisomal markers are biochemical adaptations associated with daytime RF and FEO expression.