Pathophysiological Relationship between Infections and Systemic Vasculitis. (7th July 2015)

• Record Type: Journal Article
• Authors: Muñoz-Grajales, Carolina; Pineda, Juan C.
• Other Names: Szalai Alexander Academic Editor.
• Is Part Of: Autoimmune diseases. Volume 2015(2015)
• Publication Date: 2015-07-07
• Subjects: Autoimmune diseases -- Periodicals; 571.97305
• DOI: 10.1155/2015/286783
• Languages: English
• ISSNs: 2090-0422

Abstract

Abstract : The development of autoimmune disorders requires a combination of genetic, immunological, and environmental factors. Infectious agents, such as viruses and bacteria, can trigger autoimmunity through different mechanisms, and for systemic vasculitis in particular, microbial agents have been suggested to be involved in its pathogenesis. Although the exact mechanisms have not been fully elucidated, different theories have been postulated. This review considers the role of infections in the etiology of primary vasculitis, emphasizing their related immunological events.