Putative Multifunctional Signature of Lung Metastases in Dedifferentiated Chondrosarcoma. (7th December 2011)

• Record Type: Journal Article
• Authors: Malchenko, Sergey; Seftor, Elisabeth A.; Nikolsky, Yuri; Hasegawa, Susan L.; Kuo, Sean; Stevens, Jeff W.; Poyarkov, Stas; Nikolskaya, Tatiana; Kucaba, Tamara; Wang, Min; Abdulkawy, Hakim; Casavant, Thomas; Morcuende, Jose; Buckwalter, Joseph; Hohl, Raymond; DeYoung, Barry; Kernstine, Kemp; Bonaldo, Maria de Fatima; Hendrix, Mary J. C.; Soares, Marcelo B.; Soares, Vera Maria F. C.
• Other Names: Gronchi Alessandro Academic Editor.
• Is Part Of: Sarcoma. Volume 2012(2012)
• Publication Date: 2011-12-07
• Subjects: Sarcoma -- Periodicals; 616.994
• DOI: 10.1155/2012/820254
• Languages: English
• ISSNs: 1357-714X

Abstract

Abstract : Chondrosarcomas are among the most malignant skeletal tumors. Dedifferentiated chondrosarcoma is a highly aggressive subtype of chondrosarcoma, with lung metastases developing within a few months of diagnosis in 90% of patients. In this paper we performed comparative analyses of the transcriptomes of five individual metastatic lung lesions that were surgically resected from a patient with dedifferentiated chondrosarcoma. We document for the first time a high heterogeneity of gene expression profiles among the individual lung metastases. Moreover, we reveal a signature of "multifunctional" genes that are expressed in all metastatic lung lesions. Also, for the first time, we document the occurrence of massive macrophage infiltration in dedifferentiated chondrosarcoma lung metastases.