Vitamin D Deficiency Is Not Associated with Diabetic Retinopathy or Maculopathy. (14th January 2016)

• Record Type: Journal Article
• Authors: Alam, Uazman; Amjad, Yasar; Chan, Anges Wan Shan; Asghar, Omar; Petropoulos, Ioannis N.; Malik, Rayaz A.
• Other Names: Mallone Roberto Academic Editor.
• Is Part Of: Journal of diabetes research. Volume 2016(2016)
• Publication Date: 2016-01-14
• Subjects: Diabetes -- Periodicals; Diabetes -- Pathophysiology -- Periodicals; Diabetes -- Prevention -- Periodicals; Diabetes -- Etiology -- Periodicals; Diabetes -- Epidemiology -- Periodicals; Diabetes -- Pathogenesis -- Periodicals; 616.462005
• DOI: 10.1155/2016/6156217
• Languages: English
• ISSNs: 2314-6745

Abstract

Abstract : Background . Experimental and clinical studies suggest a possible association between vitamin D deficiency and both diabetic retinopathy and maculopathy. Methods . We have performed a cross-sectional study in adults with types 1 and 2 diabetes mellitus. The relationship between the presence and severity of diabetic retinopathy and maculopathy with serum 25-hydroxyvitamin D concentration was evaluated using logistic regression analyses in the presence of demographic and clinical covariates. Results . 657 adults with diabetes were stratified based on retinopathy grading: No Diabetic Retinopathy (39%), Background Diabetic Retinopathy (37%), Preproliferative Diabetic Retinopathy (21%), and Proliferative Diabetic Retinopathy (3%), respectively. There were no differences in serum 25-hydroxyvitamin D concentrations (25(OH)D) between the groups (15.3 ± 9.0 versus16.4 ± 10.5 versus15.9 ± 10.4 versus15.7 ± 8.5 ng/mL, P = N S ). Logistic regression analysis demonstrated no statistically significant relationship between the severity of retinopathy and serum 25(OH)D. Furthermore, there was no difference in serum 25(OH)D between those with (n = 94, 14%) and those without (n = 563, 86%) Diabetic Maculopathy (16.2 ± 10.0 versus15.8 ± 9.8, P = N S ) and no relationship was demonstrated by logistic regression analyses between the two variables. Conclusions . This study has found no association between serum 25(OH)D and the presence and severity of diabetic retinopathy or maculopathy.