Cell Senescence in Myxoid/Round Cell Liposarcoma. (24th June 2014)

• Record Type: Journal Article
• Authors: Kåbjörn Gustafsson, Christina; Ståhlberg, Anders; Engtröm, Katarina; Danielsson, Anna; Turesson, Ingela; Åman, Pierre
• Other Names: Catton Charles Academic Editor.
• Is Part Of: Sarcoma. Volume 2014(2014)
• Publication Date: 2014-06-24
• Subjects: Sarcoma -- Periodicals; 616.994
• DOI: 10.1155/2014/208786
• Languages: English
• ISSNs: 1357-714X

Abstract

Abstract : Myxoid/round cell liposarcoma (MLS/RCLS) is the second most common liposarcoma type and characterized by the fusion oncogenes FUS-DDIT3 or EWSR1-DDIT3 . Previous analysis of cell cycle regulatory proteins revealed a prominent expression of G1-cyclins, cyclin dependent kinases, and their inhibitors but very few cells progressing through the G1/S boundary. Here, we extend the investigation to proteins involved in cell senescence in an immunohistochemistry based study of 17 MLS/RCLS cases. Large subpopulations of tumor cells expressed the RBL2 pocket protein and senescence associated heterochromatin 1 γ and IL8 receptor β . We conclude that MLS/RCLS tissues contain major populations of senescent tumor cells and this may explain the slow growth rate of this tumor type.