Diabetic Microangiopathy Is an Independent Predictor of Incident Diabetic Foot Ulcer. (29th February 2016)

• Record Type: Journal Article
• Authors: Tomita, Masuomi; Kabeya, Yusuke; Okisugi, Mari; Katsuki, Takeshi; Oikawa, Yoichi; Atsumi, Yoshihito; Matsuoka, Kempei; Shimada, Akira
• Other Names: Piaggesi Alberto Academic Editor.
• Is Part Of: Journal of diabetes research. Volume 2016(2016)
• Publication Date: 2016-02-29
• Subjects: Diabetes -- Periodicals; Diabetes -- Pathophysiology -- Periodicals; Diabetes -- Prevention -- Periodicals; Diabetes -- Etiology -- Periodicals; Diabetes -- Epidemiology -- Periodicals; Diabetes -- Pathogenesis -- Periodicals; 616.462005
• DOI: 10.1155/2016/5938540
• Languages: English
• ISSNs: 2314-6745

Abstract

Abstract : Aim. To determine the diabetic foot ulcer incidence and examine its association with microangiopathy complications, including diabetic retinopathy (DR) and albuminuria (Alb), in type 2 diabetes patients. Methods. This was a retrospective cohort study of 1, 305 patients with type 2 diabetes who were assigned to the following groups: Category 1, normoalbuminuria without DR (n = 712 ); Category 2, Alb without DR (n = 195 ); Category 3, normoalbuminuria with DR (n = 185 ); and Category 4, Alb with DR (n = 213 ). Cox proportional hazard models were used to compare the risks of developing diabetic foot ulcers across the categories. Results . During 14, 249 person-years of follow-up, 50 subjects developed diabetic foot ulcers, with incidence rates of 1.6/1, 000, 1.5/1, 000, 3.4/1, 000, and 12.5/1, 000 person-years in Categories 1, 2, 3, and 4, respectively. After adjusting for the presence of diabetic neuropathy and macroangiopathy, the hazard ratios and 95% confidence intervals (CIs) for the risk of diabetic foot ulcer development were 0.66 (95% CI, 0.18–2.36), 1.72 (95% CI, 0.67–4.42), and 3.17 (95% CI, 1.52–6.61) in Categories 2, 3, and 4, respectively, compared with Category 1. Conclusion . The presence of DR and Alb significantly increases the risk of diabetic foot ulcer development.