Platelet-Derived Growth Factors in Non-GIST Soft-Tissue Sarcomas Identify a Subgroup of Patients with Wide Resection Margins and Poor Disease-Specific Survival. (29th December 2010)

• Record Type: Journal Article
• Authors: Kilvaer, Thomas Karsten; Valkov, Andrej; Sorbye, Sveinung W.; Donnem, Tom; Smeland, Eivind; Bremnes, Roy Martin; Busund, Lill-Tove
• Other Names: Pollock R. Academic Editor.
• Is Part Of: Sarcoma. Volume 2010(2010)
• Publication Date: 2010-12-29
• Subjects: Sarcoma -- Periodicals; 616.994
• DOI: 10.1155/2010/751304
• Languages: English
• ISSNs: 1357-714X

Abstract

Abstract : Background . Optimal treatment of nongastrointestinal stromal tumor soft-tissue sarcomas (non-GIST STSs) is resection with wide margins. This study investigates the prognostic impact of the angiogenesis-associated platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) in non-GIST STS patients with wide and nonwide resection margins. Method . Tumor samples and clinical data from 249 patients with non-GIST STS were obtained, and tissue microarrays were constructed for each specimen. Immunohistochemistry was used to evaluate the expression of PDGF-A, -B, -C, and -D and PDGFR- α and - β . Results . In the multivariate analysis of patients with wide resection margins, high expression of PDGF-B (P = .013, HR = 2.954, and 95% CI = 1.255–6.956) and the coexpression of PDGF-B and PDGFR- α (overall;P = .016, high-low/low-high;P = .051, HR = 2.678, 95% CI = 0.996–7.200, high/high;P = .004, HR = 3.930, 95% CI = 1.542–10.015) were independent negative prognostic markers for disease-specific survival. Conclusion. PDGF-B and the coexpression of PDGF-B and PDGFR- α are strong and independent prognostic factors in non-GIST STSs with wide resection margins.