Increased Oxidation as an Additional Mechanism Underlying Reduced Clot Permeability and Impaired Fibrinolysis in Type 2 Diabetes. (18th August 2015)

• Record Type: Journal Article
• Authors: Lados-Krupa, Anna; Konieczynska, Malgorzata; Chmiel, Artur; Undas, Anetta
• Other Names: Yan Shi Fang Academic Editor.
• Is Part Of: Journal of diabetes research. Volume 2015(2015)
• Publication Date: 2015-08-18
• Subjects: Diabetes -- Periodicals; Diabetes -- Pathophysiology -- Periodicals; Diabetes -- Prevention -- Periodicals; Diabetes -- Etiology -- Periodicals; Diabetes -- Epidemiology -- Periodicals; Diabetes -- Pathogenesis -- Periodicals; 616.462005
• DOI: 10.1155/2015/456189
• Languages: English
• ISSNs: 2314-6745

Abstract

Abstract : Aims . We sought to investigate whether enhanced oxidation contributes to unfavorable fibrin clot properties in patients with diabetes. Methods . We assessed plasma fibrin clot permeation (K s, a measure of the pore size in fibrin networks) and clot lysis time induced by recombinant tissue plasminogen activator (CLT) in 163 consecutive type 2 diabetic patients (92 men and 71 women) aged 65 ± 8.8 years with a mean glycated hemoglobin (HbA1c) of 6.8%. We also measured oxidative stress markers, including nitrotyrosine, the soluble form of receptor for advanced glycation end products (sRAGE), 8-iso-prostaglandin F2 α (8-iso-PGF2 α ), oxidized low-density lipoprotein (oxLDL), and advanced glycation end products (AGE). Results . There were inverse correlations betweenK s and nitrotyrosine, sRAGE, 8-iso-PGF2 α, and oxLDL. CLT showed a positive correlation with oxLDL and nitrotyrosine but not with other oxidation markers. All these associations remained significant forK s after adjustment for fibrinogen, disease duration, and HbA1c (allP < 0.05 ), while oxLDL was the only independent predictor of CLT. Conclusions . Our study shows that enhanced oxidative stress adversely affects plasma fibrin clot properties in type 2 diabetic patients, regardless of disease duration and glycemia control.