Diabetes Complications at Presentation and One Year by Glycated Haemoglobin at Diagnosis in a Multiethnic and Diverse Socioeconomic Population: Results from the South London Diabetes Study. (18th May 2015)

• Record Type: Journal Article
• Authors: Azam, Mohsin; Marwood, Lindsey; Ismail, Khalida; Evans, Tyrrell; Sivaprasad, Sobha; Winkley, Kirsty; Amiel, Stephanie Anne
• Other Names: Noda Mitsuhiko Academic Editor.
• Is Part Of: Journal of diabetes research. Volume 2015(2015)
• Publication Date: 2015-05-18
• Subjects: Diabetes -- Periodicals; Diabetes -- Pathophysiology -- Periodicals; Diabetes -- Prevention -- Periodicals; Diabetes -- Etiology -- Periodicals; Diabetes -- Epidemiology -- Periodicals; Diabetes -- Pathogenesis -- Periodicals; 616.462005
• DOI: 10.1155/2015/587673
• Languages: English
• ISSNs: 2314-6745

Abstract

Abstract : Background . WHO's recommendation ofHbA 1c ≥ 48 mmol/mol (6.5%) as diagnostic for type 2 diabetes mellitus (T2DM) was adopted by three UK London boroughs in May 2012. The South London Diabetes (SOUL-D) study has recruited people with newly diagnosed T2DM since 2008. We compared participants diagnosed before May 2012 withHbA 1c < 48 mmol/mol to those with diagnosticHbA 1c ≥ 48 mmol/mol. Methods . A prospective cohort study of newly diagnosed T2DM participants from 96 primary care practices, comparing demographic and biomedical variables between those with diagnosticHbA 1c < 48 mmol/mol orHbA 1c ≥ 48 mmol/mol at recruitment and after one year. Results . Of 1488 participants, 22.8% had diagnosticHbA 1c < 48 mmol/mol. They were older and more likely to be white (p < 0.05 ). At recruitment and one year, there were no between-group differences in the prevalence of diabetic complications, except that those diagnosed withHbA 1c < 48 mmol/mol had more sensory neuropathy at recruitment (p = 0.039 ) and, at one year, had new myocardial infarction (p = 0.012 ) but less microalbuminuria (p = 0.012 ). Conclusions . Use ofHbA 1c ≥ 48 mmol/mol as the sole T2DM diagnostic criterion may miss almost a quarter of those previously diagnosed in South London yetHbA 1c < 48 mmol/mol may not exclude clinically important diabetes.