CYP4F2 (rs2108622) Gene Polymorphism Association with Age-Related Macular Degeneration. (29th August 2016)

• Record Type: Journal Article
• Authors: Sakiene, Ruta; Vilkeviciute, Alvita; Kriauciuniene, Loresa; Balciuniene, Vilma Jurate; Buteikiene, Dovile; Miniauskiene, Goda; Liutkeviciene, Rasa
• Other Names: Shu Xinhua Academic Editor.
• Is Part Of: Advances in medicine. Volume 2016(2016)
• Publication Date: 2016-08-29
• Subjects: Medicine -- Periodicals; Clinical medicine -- Periodicals; Clinical Medicine; Clinical medicine; Medicine; Periodicals; Electronic journals; Periodicals; 610
• DOI: 10.1155/2016/3917916
• Languages: English
• ISSNs: 2356-6752

Abstract

Abstract : Background . Age-related macular degeneration is the leading cause of blindness in elderly individuals where aetiology and pathophysiology of age-related macular degeneration are not absolutely clear. Purpose . To determine the frequency of the genotype of rs2108622 in patients with early and exudative age-related macular degeneration. Methods . The study enrolled 190 patients with early age-related macular degeneration, 181 patients with exudative age-related macular degeneration (eAMD), and a random sample of 210 subjects from the general population (control group). The genotyping of rs2108622 was carried out using the real-time polymerase chain reaction method. Results . The analysis of rs2108622 gene polymorphism did not reveal any differences in the distribution of C/C, C/T, and T/T genotypes between the early AMD group, the eAMD group, and the control group. The CYP4F2 (1347C>T) T/T genotype was more frequent in males with eAMD compared to females (10.2% versus 0.8%;p = 0.0052 ); also T/T genotype was less frequently present in eAMD females compared to healthy control females (0.8% versus 6.2%;p = 0.027 ). Conclusion . Rs2108622 gene polymorphism had no predominant effect on the development of early AMD and eAMD. The T/T genotype was more frequent in males with eAMD compared to females and less frequently present in eAMD females compared to healthy females.