In Silico Molecular Docking Analysis of Natural Pyridoacridines as Anticancer Agents. (19th December 2016)

• Record Type: Journal Article
• Authors: Sharma, Vikas; Sharma, Prabodh Chander; Kumar, Vipin
• Other Names: Yebra-Biurrun Maria Carmen Academic Editor.
• Is Part Of: Advances in chemistry. Volume 2016(2016)
• Publication Date: 2016-12-19
• Subjects: Chemistry -- Periodicals; Chemistry; Periodicals; 540
• DOI: 10.1155/2016/5409387
• Languages: English
• ISSNs: 2356-6612

Abstract

Abstract : Docking studies are proved to be an essential tool that facilitates the structural diversity of natural products to be harnessed in an organized manner. In this study, pyridoacridines containing natural anticancer pigments were subjected to docking studies using Glide (Schrodinger). Investigations were carried out to find out the potential molecular targets for these selected pigments. The docking was carried out on different cancer macromolecules involved in different cell cycle pathways, that is, CDK-2, CDK-6, Bcl-2, VEGFR-2, IGF-1R kinase, and G-Quadruplexes. CDK-6 was found to be the most suitable anticancer target for the pyridoacridines. In addition, effectiveness of the study was further evaluated by performing docking of known inhibitors against their respective selected macromolecules. However, the results are preliminary and experimental evaluation will be carried out in near future.