A Biocompatible Heterogeneous MOF–Cu Catalyst for In Vivo Drug Synthesis in Targeted Subcellular Organelles. (9th April 2019)

• Record Type: Journal Article
• Authors: Wang, Faming; Zhang, Yan; Liu, Zhengwei; Du, Zhi; Zhang, Lu; Ren, Jinsong; Qu, Xiaogang
• Is Part Of: Angewandte Chemie. Volume 131:Number 21(2019)
• Page Start: 7061
• Page End: 7066
• Publication Date: 2019-04-09
• Subjects: Bioorthogonale Chemie -- Heterogene Katalyse -- Klick-Chemie -- Subzelluläre Organellen -- Wirkstoffsynthese; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201901760
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: As a typical bioorthogonal reaction, the copper‐catalyzed azide–alkyne cycloaddition (CuAAC) has been used for drug design and synthesis. However, for localized drug synthesis, it is important to be able to determine where the CuAAC reaction occurs in living cells. In this study, we constructed a heterogeneous copper catalyst on a metal–organic framework that could preferentially accumulate in the mitochondria of living cells. Our system enabled the localized synthesis of drugs through a site‐specific CuAAC reaction in mitochondria with good biocompatibility. Importantly, the subcellular catalytic process for localized drug synthesis avoided the problems of the delivery and distribution of toxic molecules. In vivo tumor therapy experiments indicated that the localized synthesis of resveratrol‐derived drugs led to greater antitumor efficacy and minimized side effects usually associated with drug delivery and distribution.