Why is pancreatic cancer so deadly? The pathologist's view. Issue 2 (15th April 2019)

• Record Type: Journal Article
• Authors: Hruban, Ralph H; Gaida, Matthias M; Thompson, Elizabeth; Hong, Seung‐Mo; Noë, Michaël; Brosens, Lodewijk AA; Jongepier, Martine; Offerhaus, G Johan A; Wood, Laura D
• Is Part Of: Journal of pathology. Volume 248:Issue 2(2019)
• Page Start: 131
• Page End: 141
• Publication Date: 2019-04-15
• Subjects: pancreas -- pancreatic cancer -- pancreas cancer -- vein -- prognosis -- tumor immune microenvironment -- venous invasion; Pathology -- Periodicals; 616.07
• DOI: 10.1002/path.5260
• Languages: English
• ISSNs: 0022-3417

Abstract

Abstract: The remarkable aggressiveness of pancreatic cancer has never been fully explained. Although clearly multifactorial, we postulate that venous invasion, a finding seen in most pancreatic cancers but not in most cancers of other organs, may be a significant, underappreciated contributor to the aggressiveness of this disease. Copyright © 2019 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.