Total Synthesis of (3R, 4 S)‐4‐Hydroxylasiodiplodin via Ring Closing Metathesis Protocol. Issue 18 (14th May 2019)

• Record Type: Journal Article
• Authors: Reddy, Julakanti Satyanarayana; Manimala, Patel; Gangababu, Marri; Rammohan, Aluru; Yadav, Jillu Singh
• Is Part Of: ChemistrySelect. Volume 4:Issue 18(2019)
• Page Start: 5345
• Page End: 5347
• Publication Date: 2019-05-14
• Subjects: D-isoascorbic acid -- Lasiodiplodin -- Mitsunobu reaction -- Regioselective ring opening -- Ring-Closing Metathesis; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201900189
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: Total synthesis of ( 3R, 4 S )‐4‐Hydroxylasiodiplodin has been accomplished through convergent strategy using D‐isoascorbic acid and trihydroxybenzoic acid as the starting materials in an optimal reaction sequence. The salient features of the synthesis are the utilization of Stille coupling, trans‐esterification and Ring‐Closing Metathesis (RCM). Abstract : Herein we describe the total synthesis of (3R, 4 S)‐4‐Hydroxylasiodiplodin through convergent strategy using D‐isoascorbic acid and trihydroxybenzoic acid as the starting materials in an optimal reaction sequence. The salient features of the synthesis are the utilization of Stille coupling, trans‐esterification and Ring‐Closing Metathesis (RCM).