DNA Nanotechnology Enters Cell Membranes. Issue 10 (20th March 2019)

• Record Type: Journal Article
• Authors: Huo, Shuaidong; Li, Hongyan; Boersma, Arnold J.; Herrmann, Andreas
• Is Part Of: Advanced science. Volume 6:Issue 10(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-03-20
• Subjects: DNA amphiphiles -- membranes -- nanopores -- nanostructures -- vesicles; Science -- Periodicals; 505
• DOI: 10.1002/advs.201900043
• Languages: English
• ISSNs: 2198-3844

Abstract

Abstract: DNA is more than a carrier of genetic information: It is a highly versatile structural motif for the assembly of nanostructures, giving rise to a wide range of functionalities. In this regard, the structure programmability is the main advantage of DNA over peptides, proteins, and small molecules. DNA amphiphiles, in which DNA is covalently bound to synthetic hydrophobic moieties, allow interactions of DNA nanostructures with artificial lipid bilayers and cell membranes. These structures have seen rapid growth with great potential for medical applications. In this Review, the current state of the art of the synthesis of DNA amphiphiles and their assembly into nanostructures are first summarized. Next, an overview on the interaction of these DNA amphiphiles with membranes is provided, detailing on the driving forces and the stability of the interaction. Moreover, the interaction with cell surfaces in respect to therapeutics, biological sensing, and cell membrane engineering is highlighted. Finally, the challenges and an outlook on this promising class of DNA hybrid materials are discussed. Abstract : DNA nanotechnology is rapidly developing and the derived structures are combined with living systems . Thereby, DNA amphiphiles play an important role. In this Review, the interactions of this class of nucleic acids with membranes and the resulting applications are highlighted. Finally, future research directions of these emerging DNA‐based materials are discussed.