Tumor targeted micellar nanocarriers assembled from epipodophyllotoxin-based amphiphiles. Issue 19 (8th May 2019)

• Record Type: Journal Article
• Authors: Alliot, Julien; Theodorou, Ioanna; Nguyen, Dinh-Vu; Forier, Cynthia; Ducongé, Frédéric; Gravel, Edmond; Doris, Eric
• Is Part Of: Nanoscale. Volume 11:Issue 19(2019)
• Page Start: 9756
• Page End: 9759
• Publication Date: 2019-05-08
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c9nr01068h
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : Micelle-forming amphiphilic epipodophyllotoxin conjugates were synthesized and evaluated in vivo for their tumor targeting properties. Abstract : Micelle-forming amphiphilic drug conjugates were synthesized starting from a biologically active epipodophyllotoxin derivative which was covalently inserted in between a hydrophilic PEG unit and a hydrophobic stearyl chain. The epipodophyllotoxin-containing amphiphiles were assembled into the corresponding micelles which were evaluated in vivo for their tumor targeting properties.