A small-molecule probe for ratiometric photoacoustic imaging of hydrogen sulfide in living mice. Issue 42 (3rd May 2019)

• Record Type: Journal Article
• Authors: Li, Xiang; Tang, Yufu; Li, Jie; Hu, Xiaoming; Yin, Chao; Yang, Zhen; Wang, Qi; Wu, Zizi; Lu, Xiaomei; Wang, Wenjun; Huang, Wei; Fan, Quli
• Is Part Of: Chemical communications. Volume 55:Issue 42(2019)
• Page Start: 5934
• Page End: 5937
• Publication Date: 2019-05-03
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc02224d
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A small molecule ratiometric photoacoustic probe was developed for real-time monitoring of hydrogen sulfide in living mice. Abstract : A small-molecule photoacoustic probe based on cyanine dyes was developed by taking advantage of the nucleophilic substitution reaction of H2 S with chlorine. The probe demonstrated specific response to H2 S with ratiometric photoacoustic signals in the NIR region, which enabled real-time, accurate, high-resolution imaging of endogenous H2 S in vivo .