Co-crystal polymorphic control by nanodroplet and electrical confinement. Issue 18 (26th April 2019)

• Record Type: Journal Article
• Authors: Padrela, L. M.; Castro-Dominguez, B.; Ziaee, A.; Long, B.; Ryan, K. M.; Walker, G.; O'Reilly, E. J.
• Is Part Of: CrystEngComm. Volume 21:Issue 18(2019)
• Page Start: 2845
• Page End: 2848
• Publication Date: 2019-04-26
• Subjects: Crystals -- Periodicals; Crystal growth -- Periodicals; Crystallography -- Periodicals; Cristaux -- Périodiques; Cristaux -- Croissance -- Périodiques; Cristallographie -- Périodiques; 548
• DOI: 10.1039/c9ce00060g
• Languages: English
• ISSNs: 1466-8033

Abstract

Abstract : The polymorphic control of the co-crystal carbamazepine–saccharin (CBZ–SAC) metastable form II was achieved by nano-droplet confinement in tandem with droplet surface charging induced by electrospraying the precursor solution. Abstract : The polymorphic control of the co-crystal carbamazepine–saccharin (CBZ–SAC) metastable form II was achieved by nano-droplet confinement in tandem with droplet surface charging induced by electrospraying the precursor solution. Polymorphic exclusivity is independent of solvent selection. CBZ–SAC co-crystals obtained by electrospraying are compared with supercritical CO2 nano spray-drying, conventional spray-drying and solvent evaporation methods.