TRPM7 and TRPM8 Ion Channels in Pancreatic Adenocarcinoma: Potential Roles as Cancer Biomarkers and Targets. (19th July 2012)

• Record Type: Journal Article
• Authors: Yee, Nelson S.; Chan, Ada S.; Yee, Julian D.; Yee, Rosemary K.
• Other Names: Awad Wageha A. Academic Editor.; Chiarini Francesca Academic Editor.
• Is Part Of: Scientifica. Volume 2012(2012)
• Publication Date: 2012-07-19
• Subjects: Life sciences -- Periodicals; Biology -- Periodicals; Medicine -- Periodicals; Biological Science Disciplines; Medicine; Biology; Life sciences; Medicine; Periodicals; Electronic journals; Periodicals; 500
• DOI: 10.6064/2012/415158
• Languages: English
• ISSNs: 2090-908X

Abstract

Abstract : Transient receptor potential (TRP) ion channels are essential for normal functions and health by acting as molecular sensors and transducing various stimuli into cellular and physiological responses. Growing evidence has revealed that TRP ion channels play important roles in a wide range of human diseases, including malignancies. In light of recent discoveries, it has been found that TRP melastatin-subfamily members, TRPM7 and TRPM8, are required for normal and cancerous development of exocrine pancreas. We are currently investigating the mechanisms which mediate the functional roles of TRPM7 and TRPM8 and attempting to develop these ion channels as clinical biomarkers and therapeutic targets for achieving the goal of personalized therapy in pancreatic cancer.