Fucoidans Disrupt Adherence of Helicobacter pylori to AGS Cells In Vitro. (28th October 2015)

• Record Type: Journal Article
• Authors: Chua, Eng-Guan; Verbrugghe, Phebe; Perkins, Timothy T.; Tay, Chin-Yen
• Other Names: Haavik Svein Academic Editor.
• Is Part Of: Evidence-based complementary and alternative medicine. Volume 2015(2015)
• Publication Date: 2015-10-28
• Subjects: Alternative medicine -- Periodicals; 615.505
• DOI: 10.1155/2015/120981
• Languages: English
• ISSNs: 1741-427X

Abstract

Abstract : Fucoidans are complex sulphated polysaccharides derived from abundant and edible marine algae. Helicobacter pylori is a stomach pathogen that persists in the hostile milieu of the human stomach unless treated with antibiotics. This study aims to provide preliminary data to determine, in vitro, if fucoidans can inhibit the growth of H. pylori and its ability to adhere to gastric epithelial cells (AGS). We analysed the activity of three different fucoidan preparations ( Fucus A, Fucus B, and Undaria extracts). Bacterial growth was not arrested or inhibited by the fucoidan preparations supplemented into culture media. All fucoidans, when supplemented into tissue culture media at 1000 µ g mL −1, were toxic to AGS cells and reduced the viable cell count significantly. Fucoidan preparations at 100 µ g mL −1 were shown to significantly reduce the number of adherent H. pylori . These in vitro findings provide the basis for further studies on the clinical use of sulphated polysaccharides as complementary therapeutic agents.